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HiJAKing Gamma Chain Cytokine Signaling for CAR T Cell Therapy

The engineering of chimeric antigen receptor (CAR) T cells has been a significant recent advance in cancer therapy. CAR T cells are manufactured by collecting a patient’s own T cells, engineering these T cells to express a synthetic signaling molecule (the CAR) that specifically redirects the T cell response towards cancer cells, and re-infusing the…