Tag: science

  • Two Signals, One Response: How mRNA and LNPs Cooperate to Build Germinal Centers 

    Two Signals, One Response: How mRNA and LNPs Cooperate to Build Germinal Centers 

    The success of nucleoside-modified mRNA vaccines has redefined modern vaccine platform design. These vaccines deliver antigen-encoding mRNA packaged inside lipid nanoparticles (LNPs), generating potent neutralizing antibodies and durable memory B cell responses. One defining feature of mRNA vaccination is its ability to drive strong germinal center (GC) reactions – the specialized structures in lymph nodes where high-affinity antibody-secreting cells are…